May 26, 2020
Reviewed by Rachna Vanjani, MD
Polycystic ovary syndrome (PCOS) is the leading cause of infertility and, according to the CDC, affects 6-12% of women of reproductive age in the United States. Worldwide, the reported incidence is as high as 26%! While the name of this condition might lead you to believe that it’s all about the ovaries, it’s actually considered to be a “multisystem reproductive metabolic disorder” and is intimately related to the body’s ability to manage glucose and insulin effectively, with up to 70% of women with PCOS having insulin resistance.
PCOS is an imbalance in a woman’s hormone levels and frequently includes symptoms of menstrual irregularity, obesity (80% prevalence in PCOS), increased body hair, infertility, increased levels of male hormones (hyperandrogenism), high levels of insulin (hyperinsulinemia), and multiple small follicles on the ovaries. The exact cause of PCOS is not well understood, but a combination of genetic and lifestyle factors is the likely culprit.
Having PCOS puts women at major risk for developing type 2 diabetes, with more than half of women with PCOS developing type 2 diabetes by the time they reach 40 years of age. PCOS is so tied in with metabolic health that a 2012 NIH panel proposed that the name of the disease be changed from PCOS to “metabolic reproductive syndrome” to more accurately characterize it, but this has not yet come to fruition.
Given that insulin and glucose regulation are directly influenced by diet and lifestyle, much research has been done to ascertain whether optimizing diet and lifestyle can impact PCOS as part of a treatment approach, and the results are very promising.
Dietary changes that reduce exposure to glucose and insulin seem to improve PCOS symptoms and fertility for many. This article describes this research, as well as opportunities to use new metabolic tracking tools like continuous glucose monitoring (CGM) to guide daily choices that can optimize metabolic health in an effort to improve PCOS.
Insulin is a hormone vital to keeping blood glucose levels under control. While it is not entirely clear why insulin resistance affects the majority of women with PCOS, it is likely due to a combination of genetic factors (such as alterations in the insulin receptor which make women with PCOS less sensitive to insulin’s effects), and dietary and lifestyle factors (which can exacerbate chronic insulin secretion and promote insulin resistance).
When carbohydrates (and, to a lesser extent, proteins) are consumed, insulin is released from the pancreas to move glucose out of the bloodstream and into the body’s cells. Excess sugar intake, poor sleep, chronic stress, lack of physical activity, environmental toxins, and genetic factors can all lead to conditions of high glucose and insulin which, over time, render cells “numb” to the effects of insulin, a process referred to as insulin resistance. When this happens, glucose is less able to get into cells, thus more insulin is produced to help drive the excess glucose out of the bloodstream. When this process goes on for long periods of time, it can develop into prediabetes and then ultimately into type 2 diabetes. Women with PCOS have a three to ten times greater risk of developing type 2 diabetes than women without PCOS.
The question is, how are these high insulin levels affecting PCOS and infertility? The answer is multifaceted:
The story doesn’t stop there: While insulin promotes higher levels of androgens and increased androgen activity, these elevated androgen levels simultaneously cycle back to worsen insulin resistance. Androgens may:
The following figure illustrates the complex, self-perpetuating relationship between insulin and androgens, as well as their downstream effects.
If this sounds complicated... it is! However, there are various ways for women with PCOS to improve their symptoms. Research has shown that lifestyle and dietary factors can play a significant role in improving PCOS symptoms by not only contributing to weight loss, but also by directly increasing insulin sensitivity. There is no single diet for PCOS that will cure the condition, but research suggests that low glycemic index (LGI) and ketogenic diets, both of which minimize intake of refined carbohydrates (e.g. white bread, pasta, white rice, cereals), may be effective.
The glycemic index of a food refers to how much it raises blood glucose levels after consumption. A meal with a low glycemic index should not increase blood glucose and insulin levels as much as a high glycemic index meal. Low glycemic index foods include beans, legumes, non-starchy vegetables, certain fruits, nuts, seeds, tofu, and animal protein. In general, foods with higher fiber have a lower glycemic index since fiber slows digestion and makes some carbohydrates less digestible.
Several studies report that a LGI diet may be beneficial for women with PCOS.
While evidence is continuing to emerge that supports a benefit of ketogenic, low-carbohydrate, and low glycemic diets in women with PCOS, these diets can be difficult to implement and maintain. Furthermore, generalized dietary modifications may not be particularly helpful for all women, particularly in light of emerging data to suggest that the same food can have very different effects on the glucose levels in different individuals. For instance, as illustrated in the figure below, a banana can cause a huge blood glucose spike in person #1, while simultaneously producing very little glucose response in person #2. Consequently, eliminating bananas may very well have a positive impact on insulin levels and PCOS symptoms in person #1, but may have no effect at all in person #2.
Continuous glucose monitoring (CGM) may provide a more precise and individualized approach to constructing a diet that helps keep blood glucose levels stable and insulin levels low in women with PCOS. CGM allows for the measurement of blood glucose levels in real-time, offering instant and personalized feedback on dietary and lifestyle choices and whether these choices are having a positive or negative effect on processes that drive PCOS symptoms. Given this, CGM is uniquely positioned to help optimize diet and empower patients to take control over the modifiable aspects of PCOS.
CGM may also identify women with PCOS who are developing insulin resistance earlier than the other testing methods, as it provides a more detailed account of daily glucose patterns. One study showed that women with PCOS with normal glucose tolerance (i.e. they do not have a diagnosis of diabetes or prediabetes) still show differences in how their blood sugar fluctuates compared to women without PCOS.
The short answer with PCOS is that the condition is complicated, but it involves hormonal imbalances that involve both the reproductive and metabolic systems. While the exact causes are likely diverse and multifaceted, dietary and lifestyle factors play an important role in disease severity, and new tools can likely help mitigate these symptoms. Here’s the breakdown:
One way to interrupt the vicious cycle of elevated androgens and insulin resistance in PCOS is to maintain stable blood glucose and insulin levels to minimize the development of insulin resistance and its associated negative health consequences. CGM helps accomplish this by providing individuals with the necessary tools to track the foods they eat and see which ones have a low glycemic index for them. By having this personalized information, smart food choices and lifestyle changes can be made that will have long-lasting, positive effects on both PCOS symptoms and overall health.
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